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Zoo ‘devastated and outraged’ over destruction of lynx

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BORTH WILD ANIMAL KINGDOM have said they are ‘truly devastated and outraged’ that an escaped lynx was killed last night (Nov 10).

Lillith the lynx had been missing from the zoo since October 29 and had been spotted in populated areas yesterday.

The animal is roughly twice the size of a domestic cat and had been blamed for the killing of sheep, an act which the zoo denied was linked to the animal.

Borth Wild Animal Kingdom said: “We will be issuing a formal press release soon with all the details surrounding the hunting and killing of Lillith last night.

“I would like to make it clear to everyone however, that the decision to kill her was not ours and we in no way agreed to or participated in the shooting of our baby Lynx. We are truly devastated and outraged that this happened.”

A spokesperson for Ceredigion County Council said: “It is with deep regret that Ceredigion County Council reports on the humane destruction of the Eurasian Lynx that recently escaped from Borth Wild Animal Kingdom.

“Despite exhaustive multi agency efforts to recapture the class A animal, the multi-agency group responding to the incident received additional advice late on Friday afternoon, 10 November, from a specialist Veterinary Surgeon that the risk to public well-being had increased from moderate to severe due to the continued failure of the Wild Animal Kingdom to recapture the Lynx.

“The safety of the public was paramount and therefore once the Lynx had strayed over to a populated area of the community it was necessary to act decisively.”

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Police trying to track stolen tanker

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DYFED-POWYS POLICE is investigating the theft of a fuel tanker containing approximately 8,500 litres of diesel (4,000 litres of red diesel and 4,500 litres of white diesel).

The vehicle was taken from Tan Y Foel Quarry, Cefn Coch, Welshpool, between 5.30pm on Wednesday, May 23 and 6am on Thursday, May 24.

The police are asking people to see if the tanker is now in this area.

Anyone with information that can help officers with their investigation is asked to report it by calling 101. If you are deaf, hard of hearing or speech impaired text the non-emergency number on 07811 311 908, quoting Ref: DPP/0006/24/05/2018/01/C.

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Reprogrammed virus offers hope as cancer treatment

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A CANCER treatment that can completely destroy cancer cells without affecting healthy cells could soon be a possibility, thanks to research led by Cardiff University.

The team of researchers has successfully ‘trained’ a respiratory virus to recognise ovarian cancer and completely destroy it without infecting other cells. The reprogrammed virus could also be used to treat other cancers such as breast, pancreatic, lung and oral.

Dr Alan Parker from Cardiff University’s School of Medicine said: “Reprogrammed viruses are already being used in gene therapy procedures to treat a range of diseases, demonstrating they can be trained from being life-threatening into potentially lifesaving agents.

“In cancer treatment, up until now, reprogrammed viruses have not been able to selectively recognise only the cancer cells and would also infect healthy cells, resulting in unwanted side effects.

“We’ve taken a common, well-studied virus and completely redesigned it so that it can no longer attach to non-cancerous cells but instead seeks out a specific marker protein called αvβ6 integrin, which is unique to certain cancer cells, allowing it to invade them.

“In this case we introduced the reprogrammed virus to ovarian cancer which it successfully identified and destroyed.

“This is an exciting advance, offering real potential for patients with a variety of cancers.”

Once the virus enters the cancer cell it uses the cell’s machinery to replicate, producing many thousands of copies of itself, prior to bursting the cell and thereby destroying it in the process. The newly released viral copies can then bind and infect neighbouring cancer cells and repeat the same cycle, eventually removing the tumour mass altogether.

The virus also activates the body’s natural immune system, helping it to recognise and destroy the malignant cells.

The reprogrammed virus is from a group of respiratory viruses called adenoviruses. The advantage of using these viruses is that they are relatively easy to manipulate and have already been safely used in cancer treatment.

The technique used to reprogramme the virus to identify the protein common to ovarian, breast, pancreatic, lung and oral cancers could also be used to manipulate it so that it would recognise proteins common to other groups of cancers.

Additional refinement to the viral DNA could also allow the virus to produce anticancer drugs, such as antibodies, during the process of infecting cancer cells. This effectively turns the cancer into a factory producing drugs that will cause its own destruction.

The research was carried out in a laboratory, using mice with ovarian cancer, and has not yet reached clinical trials. The next step is to test the technique with other cancers, with a view to starting clinical trials in five years’ time.

Dr Catherine Pickworth from Cancer Research UK said: “It’s encouraging to see that this virus, which has been modified to recognise markers on cancer cells, has the ability to infect and kill ovarian cancer cells in the lab. Viruses are nature’s nanotechnology and harnessing their ability to hijack cells is an area of growing interest in cancer research.

“The next step will be more research to see if this could be a safe and effective strategy to use in people.”

The team includes researchers from Cardiff University; the Mayo Clinic in Rochester, USA; Glasgow University; the South West Wales Cancer Institute; and Velindre Cancer Centre.

The research was funded by Cancer Research UK, Tenovus Cancer Care and Cancer Research Wales.

The paper ‘Ad5NULL-A20 – a tropism-modified, αvβ6 integrin-selective oncolytic adenovirus for epithelial ovarian cancer therapies’ is published in Clinical Cancer Research.

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Money raised by Canolfan Padarn in the Race for Life

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STAFF and service users from Canolfan Padarn took part in this year’s Race for Life which took place on Sunday, May 13.

Service users Debbie, Lowri and Donna had been training for months as part of the centre’s healthy lifestyle group and were joined by staff members Lina, Ellie-May, Heather, Jenny, Dawn and Anwen, along with Heather’s daughter Cala, and Anwen’s daughter Jena.

Canolfan Padarn Support Worker Ellie-May Watkins said: “The crowd gave the crew great support and we’re grateful to everyone who cheered us on. We’d like to say a huge thank you to Queens Road Bowling Club for use of their facilities on the day. Previously, Canolfan Padarn raised £330 for Cancer research, we hope that we will match or exceed that in sponsorship this year.”

Canolfan Padarn is a community resource base for adults with learning disabilities in Aberystwyth, offering social, leisure and work opportunities in the local area.

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