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Swansea Uni to deliver advanced therapies

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A significant opportunity: University a centre for cell and gene therapies

SWANSEA U​NIVERSITY’S​ Medical School, through its partnership with Abertawe Bro Morgannwg University Health Board, is to be one of the centres to deliver advanced medical therapies to Wales, which is part of a major investment announced by Welsh Blood Services.

A recently formed health consortium, jointly led by the Welsh Blood Service (on behalf of NHS Wales) and the National Institute for Health Research Birmingham Biomedical Research Centre, has been awarded £7.3M of UK Government funding to ensure more patients benefit from a new generation of breakthrough therapies.

£1.5M will come directly to NHS Wales and £550K to Trakcel, a Welsh software company developing scheduling/tracking software for advanced therapies which is based upon technology developed at Swansea University.

The funding will support the Welsh Government’s commitment to developing an Advanced Therapies Strategy which will enable these therapies to be brought to Welsh patients and Advanced Therapy Medicinal Product (ATMP) companies to reach the clinical market, whilst building expertise, capability and capacity across NHS Wales to benefit patient outcomes.

Speaking of the award, Frank Atherton, Chief Medical Officer for Wales, said: “We welcome the announcement of the successful partnership between Birmingham, Nottingham and Wales NHS centres in bidding for Innovate UK monies. The project is aligned with our ambition to support the development, availability and adoption of new innovative therapies for patients in Wales. Cell- and gene-based advanced therapies offer exciting opportunities, not only for the way we treat people with previously incurable conditions, but also how we work together with industry and NHS Wales in bringing these treatments from bench to bedside.”

The NHS Wales role in the MW-ATTC consortium was led by the Welsh Blood Service, with support from Abertawe Bro Morgannwg and Cardiff & Vale University Health Boards along with the Life Sciences Hub Wales Special Interest Group on Cell and Gene Therapy, which brings together expertise from the Welsh NHS, Universities and industry in the Life Science sector.

As part of the contract award, one of the first advanced therapy treatment sites in Wales will be established within Abertawe Bro Morgannwg at the Joint Clinical Research Facility (JCRF) at Swansea University’s Medical School. The focus of the centre will be to develop the infrastructure, processes and skilled workforce required to enable patients to be cared for, from diagnosis through to post-treatment follow up.

Cath O’Brien, Director of the Welsh Blood Service and MW-ATTC Co-Director, said: “A significant opportunity exists to position Wales as a leader in clinical trial and routine delivery of cell and gene therapies to maximise Welsh patient benefit and opportunities for the national economy. The Welsh Government is committed to exploring these revolutionary developments in healthcare and we are excited to have worked alongside our consortium partners to secure funding through what was a highly competitive tendering process.”

One of the first products that will pass through the Welsh centres is that being developed by one of the consortium partners, Rexgenero and is intended to prevent the need for diabetes-related lower limb amputations for some no option patients. The incidence of diabetes is continuing to increase in Wales and already accounts for ~10% of the NHS Wales budget (£500M) with 200, 000 sufferers today rising to an estimated 500,000 by 2025. Currently around 2000 patients in Wales have non-healing lower limb ulcers that result in approximately 330 amputations per year.

The Midlands & Wales Advanced Therapy Treatment Centre (MW-ATTC) will identify barriers, challenges and solutions to facilitate future deployment and adoption of these transformative therapies within the UK healthcare system.

Advanced treatments, such as cell and gene therapies, show great promise for patients with chronic and terminal conditions that currently cannot be cured. Unlike conventional medicines, these new approaches often aim to selectively remove, repair, replace, regenerate and re-engineer a patient’s own genes, cells and tissues to restore normal function. The project will include potential treatments for arthritis, liver disease, several types of cancer, and diabetic ulcers.

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Education

Project in support of Ceredigion Lifeboat Campaign continues to grow

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PUPILS at a London school have again this term been working on maths and English projects that highlight the need to retain an all-weather lifeboat in New Quay and, having impressed a leading educational guru, the project continues to grow.

Since the RNLI’s announcement in June 2017 that it plans to strip Ceredigion of its only all-weather lifeboat, public opposition has been growing. To date, over 31,000 people have signed a petition opposing the RNLI’s downgrade plan, and the Ceredigion Lifeboat Campaign has gained the support of a number of prominent politicians and public figures, as well as pupils from an inner-city London school.

Pupils at Harris Academy St John’s Wood have again spent the summer term studying the facts and figures of future lifeboat coverage in Cardigan Bay. The project was initiated last year by maths teacher Alexandra Lay, who was looking for meaningful and engaging ways into the curriculum, and the lifeboat theme has now become a fixture on the school’s curriculum.

Alexandra, who studied at Aberystwyth University, and is a keen kayaker, explained: “When I first saw a map of the huge gap that the RNLI’s decision will leave in Cardigan Bay, I saw an opportunity to teach loci to my year 8s with a real purpose and real-life application.

“As the project developed, my young mathematicians were able to apply their understanding of bearings, loci and speed, as well as distance and time. Through studying all the facts and figures, my pupils began to feel a real sense of empathy for the New Quay community and wanted to do what they could to help save the all-weather lifeboat.”

The project was then taken up by the English department who planned a series of lessons around the history of the RNLI and the role of the all-weather lifeboat at New Quay. Pupils debated the subject in their lessons and wrote persuasive letters to the RNLI Chief Executive.

The project has now caught the attention of Alistair Smith, a prominent presenter, trainer and developer in learning, education and professional football, who works with schools and colleges across the UK and abroad.

Alexandra continued: “Alistair Smith visited the school and observed one of my lifeboat lessons. He was very impressed with what we’d achieved and offered his full support and guidance.

“Alistair’s feedback led to the Head of Teaching and Learning championing the lifeboat campaign as a cross-curricular project across the academy. Next year, the whole year 7 curriculum for the summer term will be based around the theme of saving New Quay’s lifeboat.”

The Harris Federation is a not-for-profit charity that includes 47 primary and secondary academies across London, with 32,000 pupils and 3,700 staff. The school now plans to bring a group of students New Quay for a boat trip as a prize for the best work.

Alexandra continued: “I have thoroughly enjoyed working on the project this year. The pupils are more committed than ever and this is reflected in the quality of their work. The letters and reports that they have produced show that downgrading New Quay lifeboat will unquestionably be detrimental to seafarers and members of New Quay’s local community. It is undeniable that downgrading the all-weather lifeboat at New Quay will put lives at risk.”

In response to the letters written by the students to the RNLI Chief Executive last year, an RNLI representative gave an assurance that: “The Chief Executive and Operations Director have seen the work your students produced, and have asked our Education team to respond in full.” Almost 12 months later, the students are still waiting for a response.

Alexandra concluded: “The lack of response is very disappointing given the seriousness of the issue about which my students, colleagues and I feel so concerned. It makes us wonder whether the RNLI have any evidence at all to back the decision they made.”

To find out more about the campaign to save Ceredigion’s only all-weather lifeboat, visit www.ceredigionlifeboatcampaign.org.uk or search for Ceredigion Lifeboat Campaign on Facebook.

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Education

Ceredigion music teacher presented with Honorary Fellowship

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A PERIPATETIC music teacher who worked for Ceredigion Music Service for 35 years has been presented as an Honorary Fellow of Aberystwyth University.

Originally from Treherbert in the Rhondda Valley, Alan Phillips began his music career playing brass with the local Treherbert Band whilst at school.

After leaving school he became a bricklayer – a skill which took him all over the UK and to Europe. Then, at the age of 23 he embarked on a Music degree at Aberystwyth, graduating in 1981.

After gaining a Post Graduate Certificate in Education from Cardiff, a chance encounter with some of his Aberystwyth friends led him to apply for the vacant brass peripatetic post in Ceredigion, to which he was duly appointed.

Over a 35 year career working for Ceredigion Music Service, Alan started the Aberystwyth Town Youth Band, and took numerous groups of young musicians to competitions at home and abroad.

Alan was presented as Honorary Fellow during the first of the University’s 2019 graduation ceremonies on Tuesday 16 July by Dr Rhodri Llwyd Morgan, Director of Welsh Language and External Engagement.

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Education

Hwyl yr Haf – Your guide for the summer holidays in Ceredigion

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CERED’S 2019 Hwyl yr Haf programme was launched on July 5 at Gŵyl Aber. It is the essential guide for parents looking for Welsh and bilingual activities for their children in Ceredigion over the school summer holidays.

Cered has been creating Hwyl yr Haf programmes since 2017 to coordinate Welsh language activities during the school summer holidays in the Aberystwyth area, and to raise awareness of the wealth of Welsh language activities that are on the doorstep. This year’s programme will see Hwyl yr Haf include partners in south Ceredigion for the first time to ensure that Hwyl yr Haf actvities are accessible to children, young people and families across the county.

There are a number of new and exciting activities in Hwyl yr Haf 2019 including Ceredigion Museum’s planetarium and Gwersyll yr Urdd Llangrannog’s Activity Days. There are also art, music, drama and dance workshops; Gigs Cantre’r Gwaelod’s Sunday Afternoon Series; mountain biking sessions and much more.

Non Davies is Cered’s Manager. She said: “Over ten thousand people saw our Hwyl yr Haf programme in 2018 and many of the activities sold out. With new partners such as Cardigan Castle, Gwersyll yr Urdd Llangrannog and Llandysul Library on board for the first time, this year we hope that even more Ceredigion families can enjoy a wealth of Welsh language activities over the summer holidays.”

To find Hwyl yr Haf activities search for Cered on Facebook, Twitter and Instagram or go to www.cered.cymru/hwyl-yr-haf-19.

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