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Swansea Uni to deliver advanced therapies

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A significant opportunity: University a centre for cell and gene therapies

SWANSEA U​NIVERSITY’S​ Medical School, through its partnership with Abertawe Bro Morgannwg University Health Board, is to be one of the centres to deliver advanced medical therapies to Wales, which is part of a major investment announced by Welsh Blood Services.

A recently formed health consortium, jointly led by the Welsh Blood Service (on behalf of NHS Wales) and the National Institute for Health Research Birmingham Biomedical Research Centre, has been awarded £7.3M of UK Government funding to ensure more patients benefit from a new generation of breakthrough therapies.

£1.5M will come directly to NHS Wales and £550K to Trakcel, a Welsh software company developing scheduling/tracking software for advanced therapies which is based upon technology developed at Swansea University.

The funding will support the Welsh Government’s commitment to developing an Advanced Therapies Strategy which will enable these therapies to be brought to Welsh patients and Advanced Therapy Medicinal Product (ATMP) companies to reach the clinical market, whilst building expertise, capability and capacity across NHS Wales to benefit patient outcomes.

Speaking of the award, Frank Atherton, Chief Medical Officer for Wales, said: “We welcome the announcement of the successful partnership between Birmingham, Nottingham and Wales NHS centres in bidding for Innovate UK monies. The project is aligned with our ambition to support the development, availability and adoption of new innovative therapies for patients in Wales. Cell- and gene-based advanced therapies offer exciting opportunities, not only for the way we treat people with previously incurable conditions, but also how we work together with industry and NHS Wales in bringing these treatments from bench to bedside.”

The NHS Wales role in the MW-ATTC consortium was led by the Welsh Blood Service, with support from Abertawe Bro Morgannwg and Cardiff & Vale University Health Boards along with the Life Sciences Hub Wales Special Interest Group on Cell and Gene Therapy, which brings together expertise from the Welsh NHS, Universities and industry in the Life Science sector.

As part of the contract award, one of the first advanced therapy treatment sites in Wales will be established within Abertawe Bro Morgannwg at the Joint Clinical Research Facility (JCRF) at Swansea University’s Medical School. The focus of the centre will be to develop the infrastructure, processes and skilled workforce required to enable patients to be cared for, from diagnosis through to post-treatment follow up.

Cath O’Brien, Director of the Welsh Blood Service and MW-ATTC Co-Director, said: “A significant opportunity exists to position Wales as a leader in clinical trial and routine delivery of cell and gene therapies to maximise Welsh patient benefit and opportunities for the national economy. The Welsh Government is committed to exploring these revolutionary developments in healthcare and we are excited to have worked alongside our consortium partners to secure funding through what was a highly competitive tendering process.”

One of the first products that will pass through the Welsh centres is that being developed by one of the consortium partners, Rexgenero and is intended to prevent the need for diabetes-related lower limb amputations for some no option patients. The incidence of diabetes is continuing to increase in Wales and already accounts for ~10% of the NHS Wales budget (£500M) with 200, 000 sufferers today rising to an estimated 500,000 by 2025. Currently around 2000 patients in Wales have non-healing lower limb ulcers that result in approximately 330 amputations per year.

The Midlands & Wales Advanced Therapy Treatment Centre (MW-ATTC) will identify barriers, challenges and solutions to facilitate future deployment and adoption of these transformative therapies within the UK healthcare system.

Advanced treatments, such as cell and gene therapies, show great promise for patients with chronic and terminal conditions that currently cannot be cured. Unlike conventional medicines, these new approaches often aim to selectively remove, repair, replace, regenerate and re-engineer a patient’s own genes, cells and tissues to restore normal function. The project will include potential treatments for arthritis, liver disease, several types of cancer, and diabetic ulcers.

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Education

821% increase in homeschooling for Ceredigion area

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OVER the last decade homeschooling has risen by 821% in the Ceredigion area, according to figures supplied through a Freedom of Information (FOI) request by homeschooling provider Wolsey Hall Oxford.

In 2013, figures revealed that 28 children were homeschooled in the Ceredigion area but by 2022 this had increased to 258.

In the last four years alone, the Ceredigion area has seen an overall rise in homeschooling of 52%. The number of Primary-aged children being taught at home rose from 65 to 109 (67%) and the number of Secondary-aged children has risen from 104 to 149 (43%).

These figures show that despite Covid-19 restrictions easing up, and schools re-opening, many parents have opted to continue homeschooling their children. They reflect a similar picture seen across the UK, as statistics show that there are now more than 71,515 homeschoolers – up from 59,559 in 2018 and 22,408 in 2013. Wolsey Hall Oxford has been collating this information from over 100 UK Councils through FOIs.

Wolsey Hall Oxford Principal, Lee Wilcock, comments: “What seems very apparent is that those parents who chose to try homeschooling for the first time during Covid-19 have realised how beneficial online learning can be. Homeschooling allows children to learn at their own pace and at a time which suits them. It is a much more child-centred approach to education than is available in a traditional classroom.”

Of course, the pandemic is not the only reason parents opt to homeschool their children. At Wolsey Hall we’ve found that some of the most common reasons for parents to choose homeschooling include:

Lack of progress or underachievement at mainstream schools
Frustration with teaching standards in mainstream schools
Concerns for their child’s safety/bullying
Behavioural issues that are not suitably dealt with in mainstream schooling
Medical reasons or learning difficulties that inhibit a child’s ability to learn in a conventional environment
Travelling and expat families
Gifted/higher learning potential students or those who are elite athletes/in the performing arts industry

It is also interesting to note that a well-being survey conducted by Wolsey Hall Oxford in September 2022 – and completed by 343 parents – concluded that 91.5% of parents believe that their child’s well-being has improved since they opted to homeschool.

One parent noted, “My son has thrived. He is a true (gregarious) introvert… He loves being around people socially, but it tires him out, so school left him feeling drained, with no energy for true social interactions. Being able to learn alone and quietly has left him with plenty of energy for social and extra-curricular activities – scouts/young leaders, tennis, drama club, youth group etc. He has become confident in his own abilities and also learnt when and how he can take the initiative to get help when needed.”

To find out more about these statistics or to interview any of our team members, please contact Danielle Hilton: danielle.hilton@wolseyhalloxford.org.uk

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Aberystwyth academic helping to improve British wrestling

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A LECTURER in Film Theory and Practice from Aberystwyth University is contributing towards a ‘code of better practice’ for British wrestling.

Dr Thomas Alcott from the Department of Theatre, Film and Television Studies has been invited by the All-Party Group on Wrestling at the UK Parliament to participate in a conference on the topic later this month.

The group – which includes MPs from across the political spectrum – recently led an inquiry and published the findings in April last year.

The cross party group reviewed regulation, funding, safeguarding and wellbeing in wrestling, and sought to find ways to better support and regulate the industry.

Dr Alcott’s doctoral research, which explored the relationship between audiences, stars and industry within the world of Professional Wrestling, was one of the resources used and quoted in the report.

Organised by the groups of MPs, Loughborough University and wrestling training school Playfight, the conference will be attended by academics, wrestlers, promoters and coaches.

It is intended to provide an opportunity for training and discussion, and lead to a safer and more inclusive environment.

Dr Alcott told The Ceredigion Herald: “For over a century, wrestling has been a popular form of culture and entertainment. However, a lack of clarity on whether it sits within the sector of sport or theatre has led to complexities about how the industry is governed and regulated.

“The inquiry by the All-Party Parliamentary Group on Wrestling is the first official analysis and intervention in the wrestling industry for many decades. The conference that follows the publication of the group’s report will provide an opportunity to discuss a guide of better practice to improve the industry for the future, for the benefit of both performers and fans.”

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New Japanese partnership to boost climate change research at Aberystwyth University

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ABERYSTWYTH University has signed up to a new partnership with a Japanese university in a boost to its climate change research.

The new memorandum of understanding with Ritsumeikan University includes exchanging research and joint investment in cutting-edge technology.

As part of the partnership, the two universities are collaborating on major projects studying climate change in Mexico and Japan.

In southern Mexico, a joint team will investigate records of past climate change in the region and its role in the collapse of the Classic Mayan civilisation.

Professor Sarah Davies, Head of Geography and Earth Sciences at Aberystwyth University said:

“It’s a pleasure to confirm our commitments with this new memorandum which builds on a long-standing research relationship between our two institutions. These projects will make an important contribution to our understanding of climate change, and its role in the development of human civilisation.

“Together with our Japanese partners and the support of Aberystwyth University and the Higher Education Funding Council for Wales, we have made a significant investment in our X-ray Fluorescence core scanner. This is a resource of both UK and international importance, enabling very high-resolution geochemical analysis of sediment cores to reconstruct climate variability. These joint investments in instrumentation are an important boost to our future research work.”

Professor Takeshi Nakagawa from Ritsumeikan University commented:

“We are delighted to forge even closer ties with our partners at Aberystwyth University as we conduct ground-breaking research together. The joint research on climate change is a very exciting opportunity to unlock some of humanity’s secrets and better understand our world.”

As part of the partnership, Professor Takeshi Nakagawa and Dr Ikuko Kitaba from Ritsumeikan University are visiting Aberystwyth until 14th November.

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