A CANCER treatment that can completely destroy cancer cells without affecting healthy cells could soon be a possibility, thanks to research led by Cardiff University.
The team of researchers has successfully ‘trained’ a respiratory virus to recognise ovarian cancer and completely destroy it without infecting other cells. The reprogrammed virus could also be used to treat other cancers such as breast, pancreatic, lung and oral.
Dr Alan Parker from Cardiff University’s School of Medicine said: “Reprogrammed viruses are already being used in gene therapy procedures to treat a range of diseases, demonstrating they can be trained from being life-threatening into potentially lifesaving agents.
“In cancer treatment, up until now, reprogrammed viruses have not been able to selectively recognise only the cancer cells and would also infect healthy cells, resulting in unwanted side effects.
“We’ve taken a common, well-studied virus and completely redesigned it so that it can no longer attach to non-cancerous cells but instead seeks out a specific marker protein called αvβ6 integrin, which is unique to certain cancer cells, allowing it to invade them.
“In this case we introduced the reprogrammed virus to ovarian cancer which it successfully identified and destroyed.
“This is an exciting advance, offering real potential for patients with a variety of cancers.”
Once the virus enters the cancer cell it uses the cell’s machinery to replicate, producing many thousands of copies of itself, prior to bursting the cell and thereby destroying it in the process. The newly released viral copies can then bind and infect neighbouring cancer cells and repeat the same cycle, eventually removing the tumour mass altogether.
The virus also activates the body’s natural immune system, helping it to recognise and destroy the malignant cells.
The reprogrammed virus is from a group of respiratory viruses called adenoviruses. The advantage of using these viruses is that they are relatively easy to manipulate and have already been safely used in cancer treatment.
The technique used to reprogramme the virus to identify the protein common to ovarian, breast, pancreatic, lung and oral cancers could also be used to manipulate it so that it would recognise proteins common to other groups of cancers.
Additional refinement to the viral DNA could also allow the virus to produce anticancer drugs, such as antibodies, during the process of infecting cancer cells. This effectively turns the cancer into a factory producing drugs that will cause its own destruction.
The research was carried out in a laboratory, using mice with ovarian cancer, and has not yet reached clinical trials. The next step is to test the technique with other cancers, with a view to starting clinical trials in five years’ time.
Dr Catherine Pickworth from Cancer Research UK said: “It’s encouraging to see that this virus, which has been modified to recognise markers on cancer cells, has the ability to infect and kill ovarian cancer cells in the lab. Viruses are nature’s nanotechnology and harnessing their ability to hijack cells is an area of growing interest in cancer research.
“The next step will be more research to see if this could be a safe and effective strategy to use in people.”
The team includes researchers from Cardiff University; the Mayo Clinic in Rochester, USA; Glasgow University; the South West Wales Cancer Institute; and Velindre Cancer Centre.
The research was funded by Cancer Research UK, Tenovus Cancer Care and Cancer Research Wales.
The paper ‘Ad5NULL-A20 – a tropism-modified, αvβ6 integrin-selective oncolytic adenovirus for epithelial ovarian cancer therapies’ is published in Clinical Cancer Research.
Minister opens film premiere for port stories
WALES’ Arts and Sports Deputy Minister has launched a new film charting the histories and life of five port towns in Wales and Ireland.
Premiered at Ceredigion Museum in Aberystwyth, the series of eight short documentary films and one feature-length film, At the Water’s Edge: Stories of the Irish Sea, aim to promote the ports of Fishguard, Holyhead and Pembroke Dock in Wales, and Dublin Port and Rosslare Harbour in Ireland, as well as the three ferry routes connecting them.
The films were produced as part of Ports, Past and Present, a project which explores the history and cultural heritage of the ports, showcasing stunning views of the landscapes and wildlife of the Irish Sea coast and revealing the human histories of the port communities.
In Fishguard, residents Gary Jones and Jana Davidson talk of invasions by pirates and French armies, while Hedydd Hughes explains how she teaches children about local legends. In Rosslare Harbour, the Todd family from Fishguard meet their Irish in-laws, the Fergusons.
Local historian David James shares the extraordinary story of how the son of a Japanese samurai came to plant a ginkgo tree in Pembroke Dock, and local councillor Josh Beynon explores the secret location where the Millennium Falcon was built for Star Wars: The Empire Strikes Back.
In Dublin and Holyhead, poetry by Gillian Brownson and Gary Brown celebrates the centuries old link of their ports. Historian Gareth Huws explains how traces of Bronze Age settlements can still be seen in the Ynys Môn town.
Deputy Minister for Arts and Sport, Dawn Bowden MS, who came to the premiere, said:
“Through showcasing the rich and diverse cultural history of our ports, bringing life and colour through visual arts, literature and film, the Ports, Past and Present project will not only enhance the experience of visitors of all ages and interests, but also encourage more time and money spent in these communities.
“Engaging with local communities and increasing the awareness of port heritage through panel discussions, creative workshops and talks – is an excellent opportunity to gain the support of local residents ensuring there is a careful balance which works for the local communities as well as visitors from across the Irish Sea and beyond.
“I’m delighted to launch the film which will showcase and celebrate the best each community has to offer to prospective visitors and users of the ferry ports, but also capture the multilingual and multicultural nature of the ports and their surrounding areas.”
Professor Peter Merriman, project team leader at Aberystwyth University’s Department of Geography and Earth Sciences said:
“We are delighted that the Minister has officially launched our films, which portray the rich cultural and natural heritage of these Irish and Welsh port towns. They are the result of almost three years of work by the project team and our production partners Mother Goose films, and we hope that they will inspire visitors to spend more time in the ports as they pass through them.”
The films form part of a wider tourism campaign to raise awareness of the rich coastal and maritime heritage of the five selected ports and their communities.
Project leader Professor Claire Connolly from University College Cork said: “It’s a joy to see so many images and stories from Rosslare, Dublin, Holyhead, Fishguard and Pembroke Dock on screen. The lives and cultures of the port towns come to life in the films and together they offer an extended invitation to stop and stay in these storied places.”
Ceredigion Museum is also hosting a travelling art exhibition looking at the rich coastal history and heritage of the port communities.
Over the coming months, the films will have free screenings around Wales and Ireland, and will then be released generally so that the local communities can promote their own areas.
Ports, Past and Present is funded by the European Regional Development Fund through the Ireland Wales Co-operation Programme, and operates across four institutions in Ireland and Wales, including University College Cork, Aberystwyth University, the University of Wales Trinity St David and Wexford County Council. The film has been led by a team in the Department for Geography and Earth Sciences at Aberystwyth University.
Aberystwyth Town to welcome Knife Angel sculpture
A HUGE 27-foot sculpture, made from 100,000 confiscated knives, is to be welcomed to Aberystwyth town next month (1 June) as local community groups prepare to come together to promote key prevention, anti-violence and anti-aggression messages.
Police and Crime Commissioner Dafydd Llywelyn, working alongside Dyfed-Powys Police, Aberystwyth Town Council and Ceredigion County Council is bringing the Knife Angel to Llys y Brenin square, Aberystwyth, where it will stand for four weeks as a physical reminder of the effects of violence and aggression.
The iconic sculpture – commissioned by the British Ironwork Centre in Oswestry, Shropshire and created by artist Alfie Bradley – will be on display in the town until 29 June 2022.
This will be the second time that Police and Crime Commissioner Dafydd Llywelyn has bought the Knife Angel to the Dyfed Powys Police Force area, with it’s first visit being in Newtown, Powys in January 2020. Mr Llywelyn has been keen to bring the Knife Angel back to the Force area since then, so that other communities can get involved in the key messages.
Police and Crime Commissioner Dafydd Llywelyn said; “The Knife Angel is a reminder of the devastating impact of knife crime, and any form of violence and aggression has on families and communities.
“Whilst there has been a 105% increase in knife crime in Wales over the last decade, rest assured that the Knife Angel has not been brought to Aberystwyth because of any major problem with this kind of crime in the area.
“However, we do acknowledge, that knife crimes have taken place here within the last year. Although a proportion of these were domestic, not street based, it is worrying that a small number of these involved suspects under the age of 18. I am pleased to see however that the Police and partners have come together over the last 6-months to put interventions in place to divert children from knife crime.
“Prevention of crime and diversion away from crime is essential. We hope that the Knife Angel will greatly assist us in raising critical awareness of knife crime whilst creating a widespread intolerance to violent behaviour within our communities.”
Inspector Andy Williams of Dyfed-Powys Police said: “While Dyfed-Powys Police is one of the safest places to live and work in the country, we still see the devastating effect knife crime has on our communities.
“In July last year we had a murder in Ceredigion involving a knife, when John Bell died after being stabbed in Cardigan.
“That case showed the devastation knives can have, with the loss of a life and the impact that has on Mr Bell’s loved ones, withs the man responsible rightly being sentenced to life in prison.
“The Knife Angel is a very dramatic and powerful sculpture that aims to inspire people not to turn to knife crime or even to carry a knife for protection.
“I would urge anyone to go and see it. Take your children and make a day of it to take in this poignant reminder of the dangers of violence and aggression, particularly when weapons are involved.”
Aberystwyth Town Mayor, Dr Talat Chaudhri, said: “We welcome the Knife Angel to Aberystwyth and stand together with towns and cities where knife crime is a bigger problem than it is here. There is no place for violence of any kind in our community.”
Children and young people from across Aberystwyth and neighbouring areas are being encouraged to get involved as well as community groups and organisations, in visiting the Knife Angel and taking part in engagement activities which focus on the key messages – the impact of violent crime, prevention, and diversion away from violence.
If you would like to find out more about how you, your community, school, college or university groups can get involved, please contact the Commissioner’s Engagement Team on OPCC.Communication@dyfed-powys.police.uk.
Young person celebrates kickstart job and overcomes several obstacles
22-YEAR-OLD Lee from rural Ceredigion found it challenging to secure permanent employment. Having no mode of transport as well as his diagnosis of autism and depression meant that Lee has experienced significant barriers with finding and maintaining employment. Communities For Work Plus (CFW+) provided Lee with the right tools and opportunities to find the right role for him. He now has a job at ASN Watson (Savers), with a more positive future ahead.
Lee was struggling financially with increasing debt and although he had been working in the past, the nature and environment of the work was not practical for Lee’s abilities; he was often misunderstood by employers.
After being referred to CFW+ from Job Centre Plus, Aberystwyth, Lee received support with job searches, applications, cover letters, cv writing, and interview skills. He’s now in paid employment, secured through the Kickstart Scheme. The UK Government Kickstart Scheme provides funding to employers to create jobs for 16 to 24-year-olds on Universal Credit.
Lee said: “The project helped me a lot as I struggle to know where to start when it comes to finding jobs, but this definitely helped. Communities for Work+ has got you covered!”
Communities For Work Plus is a Welsh Government funded project, delivered by Ceredigion County Council which supports individuals in or at risk of poverty, aged 16 or over, across Ceredigion and throughout Wales. Participants may be experiencing in-work poverty, unemployment, living on minimum wage, or struggling to pay basic monthly outgoings on sporadic zero-hour contracts.
Misha Homayoun-Fekri, CFW+ Mentor said: “Lee has been a pleasure to support. He was always very responsive, and we worked together every step of the way. I am so pleased for Lee that he has found a job that he can be happy in.”
Since starting his new role, Lee has become a lot more independent, his mental health has improved, and has started to save money for the future.
Councillor Wyn Thomas, Ceredigion County Council Cabinet Member for Schools, Lifelong Learning and Skills, said: “One in 100 people are on the autism spectrum. A report released by the Office for National Statistics shows that only 21.7% of autistic people are in employment; meaning that businesses are missing out on the opportunity to benefit from the strengths that autistic people can bring to the workplace. So, it’s great to hear that Lee has found an autism-friendly employer through the support provided by CFW+ and I encourage more employers to be more inclusive to all abilities when considering employees.”
If you think the project may be able to help you or if you would like more information, contact the team on 01545 574193 or email TCC-EST@ceredigion.gov.uk.
Popular This Week
Education2 weeks ago
Celebrating 10 years of the Coleg Cymraeg Cenedlaethol
Health5 days ago
No monkeypox cases identified in Wales say public health officials
News2 days ago
Aberystwyth Town to welcome Knife Angel sculpture
Education1 week ago
Wales’ first law department celebrates 120 years at Old Bailey
Community2 weeks ago
Nearly 7,000 in Wales sign up for UK’s biggest ever plastics investigation
News2 weeks ago
Japan looking at the revival of Welsh for help with the endangered Okinawan language
Business2 weeks ago
Welsh start-up numbers soar but insolvency-related activities also rise in Wales
Education2 weeks ago
Funding for music education trebled to the tune of £13.5m